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Denise Vilarinho Tambourgi

DENISE Denise Vilarinho Tambourgi

Nome científico: Tambourgi DV
Posição: Pesquisadora Principal; Diretora, Laboratório de Imunoquímica / Instituto Butantan; 
Presidente da Seção Pan-Americana da Sociedade Internacional de Toxinologia; Membro do Conselho da Sociedade Internacional de Complemento 



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http://lattes.cnpq.br/9562680870970641

CONTATO

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+55 11 2627-9727, 2627-9722
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Instituto Butantan  > Laboratório de Imunoquímica 
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Instituto Butantan
Laboratório de Imunoquímica
Av. Vital Brasil, 1500
CEP 05503-900 São Paulo, SP - Brasil

Publicações

  

2017

Félix-Silva J, Gomes JA, Xavier-Santos JB, Passos JG, Silva-Junior AA, Tambourgi DV, Fernandes-Pedrosa M. Inhibition of local effects induced by Bothrops erythromelas snake venom: Assessment of the effectiveness of Brazilian polyvalent bothropic antivenom and aqueous leaf extract of Jatropha gossypiifolia. Toxicon, 125:74-83 (2017).

Okamoto CK, van den Berg CW, Masashi M, Gonçalves-de-Andrade RM, Tambourgi DV. Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom. Toxins (Basel). 2;9(3) (2017).

2016

Corrêa MA, Okamoto CK, Gonçalves-de-Andrade RM, van den Berg CW, Tambourgi DV. Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis. PLoS One 11(4):e0153090 (2016).

Cristina de Oliveira-Lima K, Farsky SH, Lopes PH, de Andrade RM, van den Berg CW, Tambourgi DV. Microcirculation abnormalities provoked by Loxosceles spiders' envenomation. Toxicon 116: 35-42 (2016).

Duzzi B, Cajado-Carvalho D, Kuniyoshi AK, Kodama RT, Gozzo FC, Fioramonte M, Tambourgi DV, Portaro FV, Rioli V. [des-Arg(1)] -Proctolin: A novel NEP-like enzyme inhibitor identified in Tityus serrulatus venom. Peptides 80:18-24 (2016).

Guidolin FR, Tambourgi DV, Guidolin R, Marcelino JR, Okamoto CK, Magnoli FC, Queiroz GP, Dias da Silva W.Characterization of anti-crotalic antibodies. Toxicon. 2013 May; 66:7-17.

Myamoto DT, Pidde-Queiroz G, Gonçalves-de-Andrade RM, Pedroso A, van den Berg CW, Tambourgi DV. Characterization of a Gene Coding for the Complement System Component FB from Loxosceles laeta Spider Venom Glands. PLoS One 11(1): e0146992 (2016).

Myamoto DT, Pidde-Queiroz G, Pedroso A, Gonçalves-de-Andrade RM, van den Berg CW, Tambourgi DV. Characterization of the gene-encoding component C3 of the complement system from the spider Loxosceles laeta venom glands: Phylogenetic implications. Immunobiology 221(9): 953–963 (2016).

Scaramuzzi K, Tanaka GD, Neto FM, Garcia PR, Gabrili JJ, Oliveira DC, Tambourgi DV, Mussalem JS, Paixão-Cavalcante D, D'Azeredo Orlando MT, Botosso VF, Oliveira CL, Fantini MC, Sant'Anna AO. Nanostructured SBA-15 silica: An effective protective vehicle to oral hepatitis B vaccine immunization. Nanomedicine12 (8): 2241-2250 (2016).

Tanaka GD, Sant'Anna OA, Marcelino JR, Lustoza da Luz AC, Teixeira da Rocha MM, Tambourgi DV. Micrurus snake species: Venom immunogenicity, antiserum crossreactivity and neutralization potential. Toxicon 7: 59-68 (2016).

2015

Hui Wen F, Monteiro WM, Moura da Silva AM, Tambourgi DV, Mendonça da Silva I, Sampaio VS, dos Santos MC, Sachett J, Ferreira LC, Kalil J, Lacerda M. Snakebites and scorpion stings in the Brazilian Amazon: identifying research priorities for a largely neglected problem. PLoS Negl Trop Dis. 9(5): e0003701 (2015).

Kodama RT, Cajado-Carvalho D, Kuniyoshi AK, Kitano ES, Tashima AK, Barna BF, Takakura AC, Serrano SM, Dias-Da-Silva W, Tambourgi DV, Portaro FV. New proline-rich oligopeptides from the venom of African adders: Insights into the hypotensive effect of the venoms. Biochim Biophys Acta – General Subjects 1850(6):1180-7 (2015).

Paixão-Cavalcante D, Kuniyoshi AK, Portaro FC, da Silva WD, Tambourgi DV. African adders: partial characterization of snake venoms from three Bitis species of medical importance and their neutralization by experimental equine antivenoms. PLoS Negl Trop Dis 9(2):e0003419 (2015).

Pedroso A, Matioli SR, Murakami MT, Pidde-Queiroz G, Tambourgi DV. Adaptive evolution in the toxicity of a spider's venom enzymes. BMC Evol Biol 15:290 (2015).

Villas Boas IM, Pidde-Queiroz G, Magnoli FC, Gonçalves-de-Andrade RM, van den Berg CW, Tambourgi DV. A serine protease isolated from the bristles of the Amazonic caterpillar, Premolis semirufa, is a potent complement system activator. PLoS One 10(3):e0118615 (2015).

Wen FH, Monteiro WM, Moura da Silva AM, Tambourgi DV, da Silva IM, Sampaio VS, dos Santos MC, Sachett J, Ferreira LCL, Kalil J, Lacerda M. Snakebites and scorpion stings in the Brazilian Amazon: identifying research priorities for a largely neglected problem. PLoS Negl Trop Dis 9(5): e0003701 (2015).

2014

Bitencourt MAO, Lima, MCJS, Torres-Rêgo M, Fernandes JM, Silva-Junior AA, Tambourgi DV, Zucolotto SM, Fernandes-Pedrosa MF. Neutralizing Effects of Mimosa tenuiflora Extracts against Inflammation Caused by Tityus serrulatus Scorpion Venom. BioMed Research International. 2014;1-8.

Cajado Carvalho D, Kuniyoshi AK, Kodama RT, Oliveira AK, Serrano SM, Tambourgi DV, Portaro FV. Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms. Toxicol Sci 142(2):418-26 (2014).

Lima MC, Bitencourt MA, Furtado AA, Oliveira Rocha HA, Oliveira RM, Silva Júnior AA, Tabosa do Egito ES, Tambourgi DV, Zucolotto SM, Fernandes Pedrosa MD.Ipomoea asarifolia neutralizes inflammation induced by Tityus serrulatus scorpion venom.  J Ethnopharmacol. 2014 Apr 2. pii: S0378 8741(14)00250-5.

Squaiella-Baptistão CC, Marcelino JR, Ribeiro da Cunha LE, Gutiérrez JM, Tambourgi DV. Anticomplementary Activity of Horse IgG and F(ab')2 Antivenoms. Am J Trop Med Hyg. 2014 Mar;90(3):574-84.

Tambourgi DV, Fishelson Z. Preface to the special issue for the XXV International Complement Workshop. Mol Immunol. 61(2):55 (2014).

Tambourgi DV, van den Berg CW. Animal venoms/toxins and the complement system.  Mol Immunol. 2014 Jul 3. pii: S0161-5890(14)00151-5.

van den Berg CW, Tambourgi DV, Clark HW, Hoong SJ, Spiller OB, McGreal EP. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the c5a receptor. J Immunol. 2014 Feb 15;192(4):1787-95.

2013

Carvalho DC, Duzzi B, Kuniyoshi AK, Fioramonte M, Gozzo FC, Melo RL, Tambourgi DV, Rioli V, Portaro FC. Insights into scorpion venom peptides: alternative processing of β-KTx propeptide from Tityus serrulatus venom results in a new naturally occurring thimet oligopeptidase inhibitor.  Peptides. 2013 Feb; 40:30-3.

Guidolin FR, Tambourgi DV, Guidolin R, Marcelino JR, Okamoto CK, Magnoli FC, Queiroz GP, Dias da Silva W.Characterization of anti-crotalic antibodies. Toxicon. 2013 May; 66:7-17.

LARA PG, Prudente MFS, Dias NMC, Tambourgi DV, Lino-Junior RS, Spadafora-Ferreira M, Carvalhaes MS.Analysis of Spleen Cells in Susceptible and Resistant Mice with Experimental Lagochilascariosis. ISRN Parasitology. 2013;1-8.

Lopes PH, Bertani R, Gonçalves-de-Andrade RM, Nagahama RH, van den Berg CW, Tambourgi DV. Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active sphingomyelinase D: potential for toxicity after envenomation.  PLoS Negl Trop Dis. 2013 Aug 22;7(8):e2394.

Paixao-Cavalcante, D.; Dias da Silva, W.; Vilarinho Tambourgi, D. Envenomation by African adders (Bitis ssp.) induces complement activation. Molecular Immunology Volume: 56 Issue: 3 Pages: 259-260 Published: DEC 15 2013

Pidde-Queiroz G, Magnoli FC, Portaro FC, Serrano SM, Lopes AS, Paes Leme AF, van den Berg CW, Tambourgi DV. P-I snake venom metalloproteinase is able to activate the complemente system by direct cleavage of central components of the cascade.  PLoS Negl Trop Dis. 2013;7(10):e2519.

Venancio EJ, Portaro FC, Kuniyoshi AK, Carvalho DC, Pidde-Queiroz G, Tambourgi DV. Enzymatic properties of venoms from Brazilian scorpions of Tityus genus and the neutralisation potential of therapeutical antivenoms. Toxicon. 2013 Jul;69:180-90.

Villas-Boas IM, Gonçalves-de-Andrade RM, Squaiella-Baptistão CC, Sant'Anna OA, Tambourgi DV. Characterization of phenotypes of immune cells and cytokines associated with chronic exposure to Premolis semirufa caterpillar bristles extract. PLoS One. 2013 Sep 4;8(9):e71938.

 

 

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