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Solange Maria de Toledo Serrano

Solange Maria Toledo de Serrano

 

 

 

 

Nome científico: Serrano SM
Posição: Pesquisadora Principal; Pesquisador Científico-VI, Laboratório Especial de Toxinologia Aplicada (LETA) / Instituto Butantan

 

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CONTATO
 
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Instituto Butantan > Laboratório Especial de Toxinologia Aplicada (LETA) > Laboratório de Proteômica 
 enderecoEndereço
Instituto Butantan
Laboratório Especial de Toxinologia Aplicada (LETA)
Av. Vital Brasil, 1500
CEP 05503-900 São Paulo, SP - Brasil

Publicações

  

2017 

Abreu TF, Sumitomo BN, Nishiyama MY Jr, Oliveira UC, Souza GH, Kitano ES, Zelanis A, Serrano SM, Junqueira-de-Azevedo I, Silva PI Jr, Tashima AK. Peptidomics of Acanthoscurria gomesiana spider venom reveals new toxins with potential antimicrobial activity. J Proteomics 151:232-242 (2017). 

Chaves AF, Castilho DG, Navarro MV, Oliveira AK, Serrano SM, Tashima AK, Batista WL. Phosphosite-specific regulation of the oxidative-stress response of Paracoccidioides brasiliensis: a shotgun phosphoproteomic analysis. Microbes Infect. 19(1):34-46 (2017).

2016

Andrade-Silva D, Zelanis A, Kitano ES, Junqueira-de-Azevedo IL, Reis MS, Lopes AS, Serrano SM. Proteomic and glycoproteomic profilings reveal that post-translational modifications of toxins contribute to venom phenotype in snakes. J Proteome Res. 15(8):2658-75 (2016).

Augusto-de-Oliveira C, Stuginski DR, Kitano ES, Andrade-Silva D, Liberato T, Fukushima I, Serrano SM, Zelanis A. Dynamic rearrangement in snake venom gland proteome: insights into Bothrops jararaca intraspecific venom variation. J Proteome Res. 15(10):3752-3762 (2016).

Bertholim L, Zelanis A, Oliveira AK, Serrano SM. Proteome-derived peptide library for the elucidation of the cleavage specificity of HF3, a snake venom metalloproteinase. Amino Acids 48(5):1331-5 (2016).

Branco VG, Iqbal A, Alvarez-Flores MP, Sciani JM, de Andrade SA, Iwai LK, Serrano SM, Chudzinski-Tavassi AM. Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo. Biochim Biophys Acta. 1864(10):1428-35 (2016).

Campos PF, Andrade-Silva D, Zelanis A, Paes Leme AF, Rocha MM, Menezes MC, Serrano SM, Junqueira-de-Azevedo Ide L. Trends in the evolution of snake toxins underscored by an integrative omics approach to profile the venom of the colubrid Phalotris mertensi. Genome Biol Evol. 8(8):2266-87 (2016).

Castiblanco-Valencia MM, Fraga TR, Pagotto AH, de Toledo Serrano SM, Abreu PA, Barbosa AS, Isaac L. Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion. Immunobiology 221(5):679-89 (2016).

Liberato T, Troncone LR, Yamashiro ET, Serrano SM, Zelanis A. High-resolution proteomic profiling of spider venom: expanding the toxin diversity of Phoneutria nigriventer venom. Amino Acids 48(3):901-6 (2016).

Menezes MC, Imbert L, Kitano ES, Vernet T, Serrano SM. Recombinant expression of the precursor of the hemorrhagic metalloproteinase HF3 and its non-catalytic domains using a cell-free synthesis system. Amino Acids. 48(9):2205-14 (2016).

Silva TA, Smuczek B, Valadão IC, Dzik LM, Iglesia RP, Cruz MC, Zelanis A, de Siqueira AS, Serrano SM, Goldberg GS, Jaeger RG, Freitas VM. AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility. Oncotarget. 7(31):49998-50016 (2016).

Zelanis A, Menezes MC, Kitano ES, Liberato T, Tashima AK, Pinto AF, Sherman NE, Ho PL, Fox JW, Serrano SM. Proteomic identification of gender molecular markers in Bothrops jararaca venom. J Proteomics 139:26-37 (2016).

2015

Freitas-de-Sousa LA, Amazonas DR, Sousa LF, Sant'Anna SS, Nishiyama MY Jr, Serrano SM, Junqueira-de-Azevedo IL, Chalkidis HM, Moura-da-Silva AM, Mourão RH. Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species. Biochimie 118:60-70 (2015).

Kodama RT, Cajado-Carvalho D, Kuniyoshi AK, Kitano ES, Tashima AK, Barna BF, Takakura AC, Serrano SM, Dias-Da-Silva W, Tambourgi DV, Portaro FV. New proline-rich oligopeptides from the venom of African adders: Insights into the hypotensive effect of the venoms. Biochim Biophys Acta – General Subjects 1850(6):1180-7 (2015).

Santoro ML, do Carmo T, Cunha BH, Alves AF, Zelanis A, Serrano SM, Grego KF, Sant'Anna SS, Barbaro KC, Fernandes W. Ontogenetic variation in biological activities of venoms from hybrids between Bothrops erythromelas and Bothrops neuwiedi snakes. PLoS One 10(12):e0145516 (2015).

Sousa LAF, Amazonas DR, Sousa LF, Sant´Anna SS, Nishiyama-Jr MY, Serrano SM, Junqueira-De-Azevedo ILM, Chalkidis HM, Moura-Da-Silva AM, Mourão RHV. Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species. Biochimie (Paris. Print), v. 118, p. 60-70 (2015).

Zelanis A, Huesgen PF, Oliveira AK, Tashima AK, Serrano SM, Overall CM. Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. J Proteomics 113:260-7 (2015).

2014

Asega AF, Oliveira AK, Menezes MC, Neves-Ferreira AG, Serrano SM.Interaction of Bothrops jararaca venom metalloproteinases with protein inhibitors.  Toxicon. 2014 Mar; 80:1-8.

Bernardoni JL, Sousa LF, Wermelinger LS, Lopes AS, Prezoto BC, Serrano SM, Zingali RB, Moura-da-Silva AM. Functional variability of snake venom metalloproteinases: adaptive advantages in targeting different prey and implications for human envenomation. PLoS One 9(10):e109651 (2014).

Cajado Carvalho D, Kuniyoshi AK, Kodama RT, Oliveira AK, Serrano SM, Tambourgi DV, Portaro FV. Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms. Toxicol Sci 142(2):418-26 (2014).

Castilho DG, Chaves AF, Xander P, Zelanis A, Kitano ES, Serrano SM, Tashima AK, Batista WL. Exploring potential virulence regulators in paracoccidioides brasiliensis isolates of varying virulence through quantitative proteomics. J Proteome Res 13(10):4259-71 (2014).

Herrera M, Paiva OK, Pagotto AH, Segura A, Serrano SM, Vargas M, Villalta M, Jensen SD, León G, Williams DJ, Gutiérrez JM. Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia. Am J Trop Med Hyg 91(5):887-94 (2014).

Serrano SM, Oliveira AK, Menezes MC, Zelanis A. The proteinase-rich proteome of Bothrops jararaca venom.  Toxin Reviews.2014; 33:1-16.

Yamashiro ET, Oliveira AK, Kitano ES, Menezes MC, Junqueira-de-Azevedo IL, Paes Leme AF, Serrano SM. Proteoforms of the platelet-aggregating enzyme PA-BJ, a serine proteinase from Bothrops jararaca venom. Biochim Biophys Acta – Proteins and Proteomics 1844(12):2068-2076 (2014).

2013

Dias GS, Kitano ES, Pagotto AH, Sant'anna SS, Rocha MM, Zelanis A, Serrano SM. Individual variability in the venom proteome of juvenile Bothrops jararaca specimens.J Proteome Res. 2013 Oct 4;12(10):4585-98.

Fernandes de Oliveira LM, Ullah A, Masood R, Zelanis A, Spencer PJ, Serrano SM, Arni RK. Rapid purification of serine proteinases from Bothrops alternatus and Bothrops moojeni venoms.  Toxicon. 2013 Dec 15; 76:282-90.

Kitano ES, Garcia TC, Menezes MC, Tashima AK, Zelanis A, Serrano SM. Cotiarinase is a novel prothrombin activator from the venom of Bothrops cotiara. Biochimie. 2013 Aug;95(8):1655-9.

Pidde-Queiroz G, Magnoli FC, Portaro FC, Serrano SM, Lopes AS, Paes Leme AF, van den Berg CW, Tambourgi DV. P-I snake venom metalloproteinase is able to activate the complemente system by direct cleavage of central components of the cascade.  PLoS Negl Trop Dis. 2013;7(10):e2519.

Serrano SM. The long road of research on snake venom serine proteinases. Toxicon. 2013 Feb; 62:19-26

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