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Publicações

Pesquisadores devem fazer referência ao apoio da FAPESP de acordo com o seguinte modelo:  “Processo 2013/07467-1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)”

 

 

 

A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis. Ventura JS, Faria F, Batista IF, Simons SM, Oliveira DG, Morais KL, Chudzinski-Tavassi AM. Biomed Pharmacother. 2013 Apr;67(3):192-6. doi: 10.1016/j.biopha.2012.11.009. 

 

A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production. Maria DA, de Souza JG, Morais KL, Berra CM, Zampolli Hde C, Demasi M, Simons SM, de Freitas Saito R, Chammas R, Chudzinski-Tavassi AM. Invest New Drugs. 2013 Jun;31(3):493-505. doi: 10.1007/s10637-012-9871-1. 

 

A pattern-oriented specification of gene network inference processes. Trepode NW; De Farias  CRG, Barrera, Junior. Computers in Biology and Medicine 43 (2013) 1415–1427. doi: 10.1016/j.compbiomed.2013.07.008.

 

Anticomplementary Activity of Horse IgG and F(ab')2 Antivenoms. Squaiella-Baptistão CC, Marcelino JR, Ribeiro da Cunha LE, Gutiérrez JM, Tambourgi DV. Am J Trop Med Hyg. 2014 Mar;90(3):574-84. doi: 10.4269/ajtmh.13-0591. 

 

Antimicrobial action of biguanides on the viability of Acanthamoeba cysts and assessment of cell toxicity. Mafra CS, Carrijo-Carvalho LC, Chudzinski-Tavassi AM, Taguchi FM, Foronda AS, Carvalho FR, de Freitas D. Invest Ophthalmol Vis Sci. 2013 Sep 27;54(9):6363-72. doi: 10.1167/iovs.13-11990.

 

Bothropic antivenom based on monoclonal antibodies, is it possible? Frauches TS, Petretski JH, Arnholdt AC, Lasunskaia EB, de Carvalho EC, Kipnis TL, da Silva WD, Kanashiro MM. Toxicon. 2013 Sep;71:49-56. doi: 10.1016/j.toxicon.2013.05.005. 

 

Characterization of anti-crotalic antibodies. Guidolin FR, Tambourgi DV, Guidolin R, Marcelino JR, Okamoto CK, Magnoli FC, Queiroz GP, Dias da Silva W. Toxicon. 2013 May;66:7-17. doi: 10.1016/j.toxicon.2013.01.015. 

 

Characterization of phenotypes of immune cells and cytokines associated with chronic exposure to Premolis semirufa caterpillar bristles extract. Villas-Boas IM, Gonçalves-de-Andrade RM, Squaiella-Baptistão CC, Sant'Anna OA, Tambourgi DV. PLoS One. 2013 Sep 4;8(9):e71938. doi: 10.1371/journal.pone.0071938. 

 

Cotiarinase is a novel prothrombin activator from the venom of Bothrops cotiara. Kitano ES, Garcia TC, Menezes MC, Tashima AK, Zelanis A, Serrano SM. Biochimie. 2013 Aug;95(8):1655-9. doi: 10.1016/j.biochi.2013.04.006. 

 

Enzymatic properties of venoms from Brazilian scorpions of Tityus genus and the neutralisation potential of therapeutical antivenoms. Venancio EJ, Portaro FC, Kuniyoshi AK, Carvalho DC, Pidde-Queiroz G, Tambourgi DV. Toxicon. 2013 Jul;69:180-90. doi: 10.1016/j.toxicon.2013.02.012. 

 

How Trypanosoma cruzi handles cell cycle arrest promoted by camptothecin, a topoisomerase I inhibitor. Zuma AA, Mendes IC, Reignault de Souza LC, Elias MC, de Souza W, Machado CR, Motta MC. Mol Biochem Parasitol. 2014 Feb 11. pii: S0166-6851(14)00017-6. doi: 10.1016/j.molbiopara.2014.02.001. 

 

Individual variability in the venom proteome of juvenile Bothrops jararaca specimens. Dias GS, Kitano ES, Pagotto AH, Sant'anna SS, Rocha MM, Zelanis A, Serrano SM. J Proteome Res. 2013 Oct 4;12(10):4585-98. doi: 10.1021/pr4007393. 

 

Insights into scorpion venom peptides: alternative processing of β-KTx propeptide from Tityus serrulatus venom results in a new naturally occurring thimet oligopeptidase inhibitor. Carvalho DC, Duzzi B, Kuniyoshi AK, Fioramonte M, Gozzo FC, Melo RL, Tambourgi DV, Rioli V, Portaro FC. Peptides. 2013 Feb;40:30-3. doi: 10.1016/j.peptides.2012.11.019. 

 

Interaction of Bothrops jararaca venom metalloproteinases with protein inhibitors. Asega AF, Oliveira AK, Menezes MC, Neves-Ferreira AG, Serrano SM. Toxicon. 2014 Mar;80:1-8. doi: 10.1016/j.toxicon.2014.01.001. 

 

Interaction of Leptospira interrogans with human proteolytic systems enhances dissemination through endothelial cells and protease levels. Vieira ML, Alvarez-Flores MP, Kirchgatter K, Romero EC, Alves IJ, de Morais ZM, Vasconcellos SA, Chudzinski-Tavassi AM, Nascimento AL. Infect Immun. 2013 May;81(5):1764-74. doi: 10.1128/IAI.00020-13. 

 

Involvement of formyl peptide receptors in the stimulatory effect of crotoxin on macrophages co-cultivated with tumour cells. Costa ES, Faiad OJ, Landgraf RG, Ferreira AK, Brigatte P, Curi R, Cury Y, Sampaio SC. Toxicon. 2013 Nov;74:167-78. doi: 10.1016/j.toxicon.2013.08.057. 

 

Leishmania amazonensis promastigotes present two distinct modes of nucleus and kinetoplast segregation during cell cycle. da Silva MS, Monteiro JP, Nunes VS, Vasconcelos EJ, Perez AM, Freitas-Júnior Lde H, Elias MC, Cano MI. PLoS One. 2013 Nov 21;8(11):e81397. doi: 10.1371/journal.pone.0081397. 

 

Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the c5a receptor. van den Berg CW, Tambourgi DV, Clark HW, Hoong SJ, Spiller OB, McGreal EP. J Immunol. 2014 Feb 15;192(4):1787-95. doi: 10.4049/jimmunol.1301920. 

 

Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine. Machado FC, Zambelli VO, Fernandes AC, Heimann AS, Cury Y, Picolo G. Br J Pharmacol. 2014 Feb;171(4):961-72. doi: 10.1111/bph.12488.

 

Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain. Brigatte P, Konno K, Gutierrez VP, Sampaio SC, Zambelli VO, Picolo G, Curi R, Cury Y. Pharmacol Biochem Behav. 2013 Aug;109:1-7. doi: 10.1016/j.pbb.2013.04.012. 

 

Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats. Zambelli VO, Fernandes AC, Gutierrez VP, Ferreira JC, Parada CA, Mochly-Rosen D, Cury Y. PLoS One. 2014 Mar 4;9(3):e90576. doi: 10.1371/journal.pone.0090576. 

 

P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade. Pidde-Queiroz G, Magnoli FC, Portaro FC, Serrano SM, Lopes AS, Paes Leme AF, van den Berg CW, Tambourgi DV. PLoS Negl Trop Dis. 2013 Oct 31;7(10):e2519. doi: 10.1371/journal.pntd.0002519. 

 

Predicting the proteins of Angomonas deaneiStrigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family. Motta MC, Martins AC, de Souza SS, Catta-Preta CM, Silva R, Klein CC, de Almeida LG, de Lima Cunha O, Ciapina LP, Brocchi M, Colabardini AC, de Araujo Lima B, Machado CR, de Almeida Soares CM, Probst CM, de Menezes CB, Thompson CE, Bartholomeu DC, Gradia DF, Pavoni DP, Grisard EC, Fantinatti-Garboggini F, Marchini FK, Rodrigues-Luiz GF, Wagner G, Goldman GH, Fietto JL, Elias MC, Goldman MH, Sagot MF, Pereira M, Stoco PH, de Mendonça-Neto RP, Teixeira SM, Maciel TE, de Oliveira Mendes TA, Ürményi TP, de Souza W, Schenkman S, de Vasconcelos AT. PLoS One. 2013;8(4):e60209. doi: 10.1371/journal.pone.0060209. 

 

Proline dehydrogenase regulates redox state and respiratory metabolism in Trypanosoma cruzi. Paes LS, Suárez Mantilla B, Zimbres FM, Pral EM, Diogo de Melo P, Tahara EB, Kowaltowski AJ, Elias MC, Silber AM. PLoS One. 2013 Jul 22;8(7):e69419. doi: 10.1371/journal.pone.0069419. 

 

Rapid purification of serine proteinases from Bothrops alternatus and Bothrops moojeni venoms. Fernandes de Oliveira LM, Ullah A, Masood R, Zelanis A, Spencer PJ, Serrano SM, Arni RK. Toxicon. 2013 Dec 15;76:282-90. doi: 10.1016/j.toxicon.2013.10.016. 

 

Rational development of novel leads from animal secretion based on coagulation and cell targets: 1. In silico analysis to explore a peptide derivative as lipocalins' signature. Mesquita Pasqualoto KF, Carrijo-Carvalho LC, Chudzinski-Tavassi AM. Toxicon. 2013 Jul;69:200-10. doi: 10.1016/j.toxicon.2013.02.004. 

 

Repeated inoculations of Mycobacterium bovis Bacille Calmette-Guérin (BCG) are needed to induce a strong humoral immune response against antigens expressed by the bacteria. Monique C. da Silva, Elena B. Lasunskaia, Wilmar Dias da Silva  Open Journal of Immunology 3 (2013) 71-81. DOI: 10.4236/oji.2013.33011.

 

Structural characterization of the cell division cycle in Strigomonas culicis, an endosymbiont-bearing trypanosomatid. Brum FL, Catta-Preta CM, de Souza W, Schenkman S, Elias MC, Motta MC. Microsc Microanal. 2014 Feb;20(1):228-37. doi: 10.1017/S1431927613013925.

 

Structural Findings and Molecular Modeling Approach of a TFPI-Like Inhibitor. Pasqualoto KF, Balan A, Barreto SA, Simons SM, Chudzinski-Tavassi AM. Protein Pept Lett. 2014 May;21(5):452-7.

 

The anti-inflammatory action of Bothrops jararaca snake antithrombin on acute inflammation induced by carrageenan in mice. de Morais-Zani K, Nunes FP, da Silva JB, Ferreira MJ, Grego KF, Lopes-Ferreira M, Tanaka AS, Tanaka-Azevedo AM. Inflamm Res. 2013 Aug;62(8):733-42. doi: 10.1007/s00011-013-0628-x. 

 

The hierarchical process of differentiation of long-lived antibody-secreting cells is dependent on integrated signals derived from antigen and IL-17A. Grund LZ, Lopes-Ferreira M, Lima C. PLoS One. 2013 Sep 18;8(9):e74566. doi: 10.1371/journal.pone.0074566. 

 

The long road of research on snake venom serine proteinases. Serrano SM. Toxicon. 2013 Feb;62:19-26. doi: 10.1016/j.toxicon.2012.09.003. Review.

 

The longevity of Th2 humoral response induced by proteases natterins requires the participation of long-lasting innate-like B cells and plasma cells in spleen. Komegae EN, Grund LZ, Lopes-Ferreira M, Lima C. PLoS One. 2013 Jun 28;8(6):e67135. doi: 10.1371/journal.pone.0067135. 

 

TLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells. Komegae EN, Grund LZ, Lopes-Ferreira M, Lima C. PLoS One. 2013 Aug 5;8(8):e71185. doi: 10.1371/journal.pone.0071185. 

 

Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active sphingomyelinase D: potential for toxicity after envenomation. Lopes PH, Bertani R, Gonçalves-de-Andrade RM, Nagahama RH, van den Berg CW, Tambourgi DV. PLoS Negl Trop Dis. 2013 Aug 22;7(8):e2394. doi: 10.1371/journal.pntd.0002394. 

 

Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. Costa ET, Barnabé GF, Li M, Dias AA, Machado TR, Asprino PF, Cavalher FP, Ferreira EN, Del Mar Inda M, Nagai MH, Malnic B, Duarte ML, Leite KR, de Barros AC, Carraro DM, Chammas R, Armelin HA, Cavenee W, Furnari F, Camargo AA. Oncogene. 2014 Mar 24;0. doi: 10.1038/onc.2014.70. 

 

Fibroblast growth factor 2 causes G2/M cell cycle arrest in ras-driven tumor cells through a Src-dependent pathway. Salotti J, Dias MH, Koga MM, Armelin HA. PLoS One. 2013 Aug 26;8(8):e72582. doi: 10.1371/journal.pone.0072582. 

 

Oleic, linoleic and linolenic acids increase ros production by fibroblasts via NADPH oxidase activation. Hatanaka E, Dermargos A, Hirata AE, Vinolo MA, Carpinelli AR, Newsholme P, Armelin HA, Curi R. PLoS One. 2013 Apr 8;8(4):e58626. doi: 10.1371/journal.pone.0058626. 

 

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